Comparison of Two Different Semiquantitative Urinary Dipstick Tests with Albumin-to-Creatinine Ratio for Screening and Classification of Albuminuria According to KDIGO. A Diagnostic Test Study

Background: Semiquantitative dipstick tests are utilized for albuminuria screening. Methods: In a prospective cross-sectional survey, we analyzed the diagnostic test validity of semiquantitative colorimetric indicator-dye-based Combur9-Test® and albumin-specific immunochromatographic assay Micral-Test® detection albuminuria, distribution measurements within stages according to KDIGO, utility screening compared with an albumin-to-creatinine ratio (ACR) in walk-in population. Results: 970 subjects, (≥30 mg/g) was detected 12.7% (95% CI 85.6–96.3%) ACR. Sensitivity 82.9% 75.1–89.1%) 91.9% 88.7–96.9%) specificity 71.5% 68.4–74.6%) 17.5% 15.0–20.2%) Micral-Test®, respectively. Correct classification KDIGO A2/A3 15.4%, 51.4%, 87.9% at cut-offs 30, 100, ≥300 mg/dL, it 1.8%, 10.5%, 53.6% 2, 5, 10 Overall, disagreement seen 27% 73% From total population, 62.5% 15.3% were correctly ruled out 2.2% 1% missed as false-negatives by Conclusion: Compared Combur9-Test®, is limited, because fraction patients small large proportion positive require subsequent ACR conformation test.